NIH Post-Acute Sequelae of SARS-CoV-2 Infection Initiative

February 24, 2021

The NIH has published two Research Opportunity Announcements (ROAs) as part of its new Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) initiative.  NIH is soliciting proposals for research that will improve understanding of and contribute to strategies to prevent and treat post-acute manifestations of SARS-CoV-2 infection across the lifespan. Projects will be funded utilizing NIH’s Other Transaction Authority (OTA), which offers flexibility and the ability to engage partners in collaborative innovation and problem solving. 

  • A Recovery Cohort ROA soliciting proposals for studies involving (a) clinical recovery cohorts, (b) EHR and other real-world data, and (c) autopsy cohorts; proposals must be received by 5:00 p.m., March 23, 2021.
  • A Cores ROA soliciting proposals for (a) a Data Resource Core, (b) a Clinical Studies Core, and (c) a Biospecimen Core; proposals must be received by 5:00 p.m., March 16, 2021.

Applicants may apply to perform one, two, or all three elements of each ROA. 

If you are interested in learning more about these ROAs, please click on the links above. In addition, you may reference Frequently Asked Questionsspecific to this opportunity. Potential applicants are also strongly encouraged to register for and attend a Technical Assistance Workshop on March 1 at 5:00 p.m. ET to learn more. If after reviewing these materials you have additional questions, you may direct them to