Case Study: Examining Pregnancy-Related Morbidity at Duke and UNC

Duke CTSI announces the publication of a new case study, “Maternal Morbidity at Duke and UNC: A Multicenter Examination of Risk Factors and Trends of Pregnancy-Related Morbidity,” a research project led by Marie-Louise Meng, MD, co-principal investigator for Duke University, and Johanna Quist-Nelson, MD, co-principal investigator for the University of North Carolina at Chapel Hill.

Over the past 30 years, maternal morbidity and mortality rates in the United States have more than doubled. Rates now exceed other high-income nations, and there are severe disparities in maternal mortality. This research determines the severe maternal morbidity rate (SMM) at Duke and UNC and examines racial and ethnic disparities within those morbidity events.

This case study discusses research methods and results and explores the challenges the researchers faced, as well as the strategies they used to overcome those obstacles. For non-research audiences, it offers an accessible way to understand the science and its benefits to society.

The case study includes:

  • Significance, goals, and approach of the project

  • Research team composition

  • Challenges and learnings

  • Timeline of funding and milestones

  • Summary of benefits, demonstrated and potential


This is the sixth in a series of Duke CTSI case studies using the Translational Science Benefits Model (TSBM) framework, which details the path of a research project from idea to impact.


The Translational Science Benefits Model is a framework that public health and clinical scientists can use to demonstrate the impact of their work in the real world.

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