OneDukeGen is a precision medicine study that aims to advance healthcare through cutting-edge genomics, biomarker discovery and implementation research. The study team is recruiting over 100,000 Duke Health system patients and collecting biospecimens, surveys, and electronic health record data, with the goal of integrating genomics, biomarker, and health data to foster a deeper understanding of a variety of disease susceptibilities. It is being conducted through the Duke Center for Precision Health.
OneDukeGen focuses on health system patients, making us unique from population-based studies. This approach enables us to pair biospecimens with rich, deeply-phenotyped and longitudinal health data and imaging across a variety of diseases, as well as flexibility in study design and ability to re-engage research participants in other studies.
Our Data
OneDukeGen is consenting over 100,000 participants over the next few years through on-site or remote (home-based) enrollment, including consenting to be contacted about future research opportunities.
We also have a virtual biorepository of health data, genomics, and other biomarker data, paired with biospecimens in >100,000 participants across diverse diseases.
Data availability includes
- DNA sequencing data
- Whole Genome Sequencing (WGS)
- Blended Genome Exome (BGE)
- Biospecimens
- Whole blood EDTA
- Whole blood Tempus RNA
- Plasma
- Stool samples
- Electronic Health Records (EHR)
- PCORnet-mapped in-patient and out-patient diagnoses codes
- Procedures
- Medications
- Laboratory values
- Structured and unstructured clinical imaging
- Self-report survey data
- Demographics
- Health views
- Genetics beliefs and knowledge
- Personal and family medical history
- Healthcare utilization
- Social Determinants of Health
- Robust data available regarding SDOH domains from both EHR and survey data.
- Robust data available regarding SDOH domains from both EHR and survey data.
- Return of genetic results
- Returning some genetic findings to research participants
- Welcoming collaborations around return of results
Discover the OneDukeGen cohort
As of June 2025, there are >12,000 participants enrolled in OneDukeGen. Participant demographics and some disease prevalences are displayed below. We have the ability to query structured and unstructured data across a variety of health and disease phenotypes for existing or potential new OneDukeGen participants.
Aggregate deidentified participant data are available to Duke collaborators in an interactive dashboard that functions as a self-service data exploration tool. For security reasons, the dashboard may be accessed only with Duke credentials (via single sign-on) while on the Duke network or connected to VPN.
Visit the OneDukeGen Data Exploration Tool
*Password protected
*Text version of graphic available
How OneDukeGen is Being Used
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The OneDukeGen approach differs from other population-based studies with our focus on hospital-based patients to enable pairing of biospecimens with rich, deeply-phenotyped and longitudinal health data across a variety of diseases. Genomic and biomarker research is being conducted through this careful phenotyping, facilitating higher yield and more precise discovery.
- Genomics education and return of results
By analyzing survey and EHR data with interventions, the OneDukeGen study team will be able to provide improvements for participant education, receiving research genet results, and establishing care for a new genetic risk. Our goal is to create a participant experience that allows for autonomy and access to appropriate care, when desired.
- Implementation science and healthcare utilization research
We want to know what happens to our participants’ health journeys once they receive their research genetic results. We will utilize a combination of semi-structured interviews, surveys, and EHR analyses to understand what patients do with their new health information and what barriers they face in obtaining care. We also have a variety of implementation science efforts including assessing rural attitudes about genomics; studying associations between recruitment methods and participation in research on genomic sequencing; understanding the role of social determinants of health.
- Genetic disease research
We are studying natural history of genetic disease and understanding the penetrance and variable expressivity in our cohort.
- Gut microbiome
By collecting stool samples from a subset of participants, we will study the effects of the gut microbiome on health and disease.
- Biospecimen biorepository
We are establishing a multi-functional cell line repository in a subset of participants and creating a repository of nasal and intestinal organoids to study how infections interact with the intestine.
Innovate With Us
The OneDukeGen study team welcomes opportunities for research collaborations. We are collecting electronic health record and survey data and biospecimens from a large cohort of participants across a diverse spectrum of health and disease and conducting genomic and other biomarker assessments.
Potential collaborations include:
- research on existing data;
- use of banked biospecimens;
- new survey deployments to OneDukeGen participants;
- research around return of results and community engagement;
- new biospecimen or data collection in additional Duke Health System patients;
- recruitment of the engaged OneDukeGen participants into new research studies.
Interested in collaborating with us? Please complete our interest form. We will use your provided information to evaluate feasibility and further discussion. Thank you for your interest in collaboration!
Duke researchers interested in the Federated Clinical Analytics Platform should visit the FCAP SharePoint site. For security reasons, this site may be accessed only with Duke credentials (via single sign-on).