Sharing new knowledge with others in the scientific community helps to advance expertise and understanding about a particular disease and raise awareness of best practices and practical applications associated with treatments and interventions.
Through the publication of scientifically grounded research in peer-reviewed journals, clinicians and researchers disseminate this knowledge to others in the same field of study.
Duke CTSI supports investigators and research teams in this process of knowledge-sharing through a variety of means, including the publication of findings in high-quality journals. Review a sampling below of CTSI-supported publications disseminated in 2023, and see the complete lists of CTSA publications and Duke Kannapolis publications from the past year.
The 5Ws of Racial Equity in Research: A Framework for Applying a Racial Equity Lens Throughout the Research Process | Health Equity
An article by Keisha Bentley-Edwards, PhD, co-director of the CTSI Equity in Research and Integration of Special Populations cores, and other CTSI co-authors introduced a framework for advancing racial equity in research processes, environments, and among the research workforce.
Predictive Accuracy of Stroke Risk Prediction Models Across Black and White Race, Sex, and Age Groups | Journal of the American Medical Association
Duke CTSA KL2 alumni Michael Cary, PhD, RN, and CTSI Data Science Core Director Michael Pencina, PhD, co-authored a paper about the accuracy of stroke risk prediction models across demographics.
Discriminative Accuracy of the CAPTURE Tool for Identifying Chronic Obstructive Pulmonary Disease in US Primary Care Settings | Journal of the American Medical Association
Rowena Dolor, MD, MHS, co-authored a publication about a new tool that shows promise in helping primary care physicians identify adults with undiagnosed chronic obstructive pulmonary disease (COPD). Dolor directs the Duke Primary Care Research Consortium (PCRC), a primary care research network for the academic and community practices within the Duke Health System and surrounding communities.
Needles in a Haystack: Finding Qualitative and Quantitative Collaborators in Academic Medical Centers | Academic Medicine
Members of the Duke CTSI Biostatistics, Epidemiology, and Research Design (BERD) Core are featured in a publication focused on finding qualitative and quantitative collaborators in academic medical centers.
Serum Pro‐N‐Cadherin Is a Marker of Subclinical Heart Failure in the General Population | Journal of the American Heart Association
New research using biospecimens from Duke CTSI’s MURDOCK Study suggests that serum pro‐N‐cadherin is an early marker of subclinical heart failure. The finding has the potential to identify patients who would benefit from intervention before they show signs of disease. Salvatore Vincent Pizzo, MD, and his Duke Pathology team used samples and more than 13 years of clinical data from 690 MURDOCK participants in their research.
COVID-19 Infection Risk Among Previously Uninfected Adults: Development of a Prognostic Model | Sage Journals
A handful of key variables can predict risk for COVID-19 infection, according to a model developed with data from CTSI’s pandemic research project at Duke Kannapolis. The research, led by C3PI study PI L. Kristin Newby, MD, MHS, and co-PI Chris Woods, MD, MPH, provides a foundation for development of a tool that could assess risk, guide clinical decisions, and help allocate healthcare resources.
Population Health Improvement Awards: Supporting Community and Academic Capacity to Partner in Research and Improve Population Health | Journal of Community Engagement and Scholarship
This article by members of Duke CTSI’s Community Engaged Research Initiative (CERI) detailed the Population Health Improvement Awards program, focusing on how these awards support community and academic partnerships in research to improve population health.
Describing current use, barriers, and facilitators of patient portal messaging for research recruitment: Perspectives from study teams and patients at one institution | Journal of Clinical and Translational Science
This article by members of the Duke CTSI Recruitment Innovation Center team focused on patient portal messaging as a mechanism for research recruitment, featuring perspectives from study teams and participants.
Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma ADRD Biomarkers in the Duke Physical Performance Across the LifeSpan Study | Journal of Alzheimer’s Disease
This research led by Daniel C. Parker, MD, used samples and data from a cohort of the MURDOCK Study to better understand Alzheimer’s disease and related dementias (ADRD). The Duke Pepper Center found indications that dysregulated kynurenine pathway metabolism may play a role in the development of ADRD.
Recommendations for using the 5Ts Framework to support research inclusion across the lifespan | Journal of the American Geriatrics Society
A research letter by members of Duke CTSI's Integrating Special Populations team offered recommendations for using the 5Ts Framework to support research inclusion. This research was conducted in collaboration with the Duke Department of Population Health Sciences, the Duke Division of Geriatrics, and the Oregon Clinical and Translational Science Institute.
Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case-control study | Osteoporosis International
Older adults with type 2 diabetes are more likely to break a bone, even though they have higher bone mineral density. To better understand this paradox, Duke researchers led by Richard H. Lee, MD used MURDOCK Study samples, self-reported incident fractures, and electronic medical records to assess the association between fractures and metabolic profile.
Laying the groundwork to make diversity, equity, and inclusion front and center in clinical and translational research | Journal of Clinical and Translational Science
Several CTSI faculty and staff members authored an article that proposes how to focus on diversity, equity, and inclusion in clinical and translational research projects.
Now is the time to fix the clinical research workforce crisis | Clinical Trials
Members of the CTSA's Participant and Clinical Interactions (PCI) Core authored two publications on the clinical research workforce and clinical research infrastructure.
One article outlined ways to fix the clinical research workforce crisis.
Leveraging retooled clinical research infrastructure for Clinical Research Management System implementation at a large Academic Medical Center | Journal of Clinical and Translational Science
Members of the CTSA's Participant and Clinical Interactions (PCI) Core authored two publications on the clinical research workforce and clinical research infrastructure. One article focused on how to optimize research management system integration at a large academic medical center.
Stagnant daily smoking prevalence between 2008 and 2019 among Black and Hispanic adults with serious psychological distress | Drug and Alcohol Dependence
According to new research, daily smoking in the United States has been stagnant between 2008-2019 among Black and Hispanic adults with serious psychological distress, despite decreasing among white adults and adults without serious psychological distress. Dana Rubenstein, a Duke CTSA TL1 Scholar, and Joe McClernon, PhD, co-director for CTSI's Integration and Strategic Partnerships Pillar, are among the co-authors.
The Black Reparations Project: A Handbook for Racial Justice
Keisha Bentley-Edwards, PhD, wrote a chapter detailing the disproportionate and unresolved African American health burden in a groundbreaking resource that moves the country from theory to action with a practical plan for reparations. This book gathered an accomplished interdisciplinary team of scholars—members of the Reparations Planning Committee—who have considered the issues pertinent to making reparations happen. A developmental psychologist, Dr. Bentley-Edwards co-directs both the CTSI Equity in Research and CTSA Integrating Special Populations cores.
Mitigating Racial And Ethnic Bias And Advancing Health Equity In Clinical Algorithms: A Scoping Review | Health Affairs
Michael Cary, PhD, RN, authored an article based on a scoping review of healthcare frameworks and approaches for managing racial and ethnic biases. The article was published in the journal's special issue on structural racism in health. A former Duke CTSA KL2 scholar and the inaugural Duke AI Health Equity Scholar, Dr. Cary serves as the Elizabeth C. Clipp Term Chair of Nursing at the Duke School of Nursing.
Factors Associated with COVID-19 Vaccination Promptness after Eligibility in a North Carolina Longitudinal Cohort Study | Vaccines
Analysis of a COVID-19 research study based at CTSI’s Duke Kannapolis site found that education level, household income, and baseline intention were associated with longer times to vaccination, and the most common reasons for not being vaccinated were safety concerns, side effects, and vaccine effectiveness. A group of Duke authors led by L. Kristin Newby, MD, MHS, and Christopher W. Woods, MD, detailed research done as a part of the MURDOCK Cabarrus County COVID-19 Prevalence and Immunity (C3PI) Study.
Fatigue, pain interference, and psychiatric morbidity in multiple sclerosis: The role of childhood stress | PLOS ONE
Childhood stress may predict pain, fatigue, and mental illness in adults with multiple sclerosis, according to a study led by Carri Polick, PhD, a clinical associate in the Duke University School of Nursing and Duke National Clinician Scholars Program (NCSP) postdoctoral fellow. The findings support efforts to integrate trauma-informed care and screenings for stressors into clinical practice.
Systemic Racism Affecting Latinx Population Health During the COVID-19 Pandemic and Beyond: Perspectives of Latinx Community Health Workers and Community-Based Organization Leaders | Health Affairs
Duke National Clinician Scholars Program (NCSP) participant Gabriela Plasencia, MD, authored a paper focused on how systemic racism affected Latinx population health during the COVID-19 pandemic and beyond, including perspectives from Latinx community health workers and community-based organization leaders.