Clinical Data Research Networks

Clinical Data Tools
Duke Dataset Inventory
Population Health Data Sets
EHR Data Consultation Services

Duke participates in several Clinical Data Research Networks (CDRNs), making it easier to conduct multi-site research by allowing potential access to EHR data at all member institutions, including Duke.

Benefits of leveraging the CDRN program:

  • Quickly get counts of patients meeting your inclusion/exclusion criteria
  • Assess feasibility of multi-site studies
  • Find collaborators at other member institutions
  • Navigate the associated regulatory processes

Our team can help you learn about the Duke CDRN program and the process for accessing CDRN resources. Contact us to get started with clinical data.


CDRNs available to Duke investigators

Mid South Alliance logo Mid-South CDRN/PCORnet

  • Scope: Regional (Mid-South) to National (PCORnet)
  • Population: ~65 M Patients (Mid-South) to ~122 M Patients (PCORnet)
  • Who is Involved:The Mid-South Alliance is made up of leading institutions in North Carolina, South Carolina, and Tennessee. PCORnet is a national "network of networks" with more than two dozen partners, including Mid-South.

The Mid-South CDRN is a node in the national PCORnet system, bringing together academic health centers, community hospitals, and outpatient practices to support research projects. For more detailed information about what is available to investigators using the Midsouth CDRN, please download the latest PCORnet MidSouth Metadata workbook here.

  ACT Network logo ACT Network

  • Scope: National
  • Population: ~100 M
  • Who Is Involved: 32 CTSA institutions (16 more currently staging)

The ACT Network is a real-time platform allowing researchers to explore and validate feasibility for clinical studies from their desktop. Use it to discover patient cohorts at more than 32 sites across the nation. Duke CTSI has made the ACT Network available to all Duke researchers at no cost, but you must request access to receive credentials in the ACT portal.

Request access here.

Once registration is complete and you have received your credentials, you can use i2b2 to query Duke EHR-data and SHRINE to query Duke and the entire network for aggregate counts.

  Carolinas Collaborative logo Carolinas Collaborative

  • Scope: Regional (NC, SC)
  • Population: ~12 M Patients
  • Who Is Involved: Duke, UNC-CH, Wake Forest, Health Sciences South Carolina

This is a collaboration between four different health care organizations in North and South Carolina, who have agreed to share their clinical data in a federated manner to support clinical research. The Carolinas Collaborative is funded by the Duke Endowment.